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Genetically Engineered Babies Are Banned in the US. But Tech Titans Are Trying to Make One Anyway

2 months 1 week ago
"For months, a small company in San Francisco has been pursuing a secretive project: the birth of a genetically engineered baby," reports the Wall Street Journal: Backed by OpenAI chief executive Sam Altman and his husband, along with Coinbase co-founder and CEO Brian Armstrong, the startup — called Preventive — has been quietly preparing what would amount to a biological first. They are working toward creating a child born from an embryo edited to prevent a hereditary disease.... Editing genes in embryos with the intention of creating babies from them is banned in the U.S. and many countries. Preventive has been searching for places to experiment where embryo editing is allowed, including the United Arab Emirates, according to correspondence reviewed by The Wall Street Journal... Preventive is in the vanguard of a growing number of startups, funded by some of the most powerful people in Silicon Valley, that are pushing the boundaries of fertility and working to commercialize reproductive genetic technologies. Some are working on embryo editing, while others are already selling genetic screening tools that seek to account for the influence of dozens or hundreds of genes on a trait. They say their ultimate goal is to produce babies who are free of genetic disease and resilient against illnesses. Some say they can also give parents the ability to choose embryos that will have higher IQs and preferred traits such as height and eye color. Armstrong, the cryptocurrency billionaire, is leading the charge to make embryo editing a reality. He has told people that gene-editing technology could produce children who are less prone to heart disease, with lower cholesterol and stronger bones to prevent osteoporosis. According to documents and people briefed on his plans, he is already an investor or in talks with embryo editing ventures... After the Journal approached people close to the company last month to ask about its work, Preventive announced on its website that it had raised $30 million in investment to explore embryo editing. The statement pledged not to advance to human trials "if safety cannot be established through extensive research..." Other embryo editing startups are Manhattan Genomics, co-founded by Thiel Fellow Cathy Tie, and Bootstrap Bio, which plans to conduct tests in Honduras. Both companies are in early stages. The article notes the only known instance of children born from edited embryos was in 2018, when Chinese scientist He Jiankui "shocked the world with news that he had produced three children genetically altered as embryos to be immune to HIV. He was sentenced to prison in China for three years for the illegal practice of medicine. "He hasn't publicly shared the children's identities but says they are healthy.

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EditorDavid

Python Foundation Donations Surge After Rejecting Grant - But Sponsorships Still Needed

2 months 1 week ago
After the Python Software Foundation rejected a $1.5 million grant because it restricted DEI activity, "a flood of new donations followed," according to a new report. By Friday they'd raised over $157,000, including 295 new Supporting Members paying an annual $99 membership fee, says PSF executive director Deb Nicholson. "It doesn't quite bridge the gap of $1.5 million, but it's incredibly impactful for us, both financially and in terms of feeling this strong groundswell of support from the community." Could that same security project still happen if new funding materializes? The PSF hasn't entirely given up. "The PSF is always looking for new opportunities to fund work benefiting the Python community," Nicholson told me in an email last week, adding pointedly that "we have received some helpful suggestions in response to our announcement that we will be pursuing." And even as things stand, the PSF sees itself as "always developing or implementing the latest technologies for protecting PyPI project maintainers and users from current threats," and it plans to continue with that commitment. The Python Software Foundation was "astounded and deeply appreciative at the outpouring of solidarity in both words and actions," their executive director wrote in a new blog post this week, saying the show of support "reminds us of the community's strength." But that post also acknowledges the reality that the Python Software Foundation's yearly revenue and assets (including contributions from major donors) "have declined, and costs have increased,..." Historically, PyCon US has been a source of revenue for the PSF, enabling us to fund programs like our currently paused Grants Program... Unfortunately, PyCon US has run at a loss for three years — and not from a lack of effort from our staff and volunteers! Everyone has been working very hard to find areas where we can trim costs, but even with those efforts, inflation continues to surge, and changing U.S. and economic conditions have reduced our attendance... Because we have so few expense categories (the vast majority of our spending goes to running PyCon US, the Grants Program, and our small 13-member staff), we have limited "levers to pull" when it comes to budgeting and long-term sustainability... While Python usage continues to surge, "corporate investment back into the language and the community has declined overall. The PSF has longstanding sponsors and partners that we are ever grateful for, but signing on new corporate sponsors has slowed." (They're asking employees at Python-using companies to encourage sponsorships.) We have been seeking out alternate revenue channels to diversify our income, with some success and some challenges. PyPI Organizations offers paid features to companies (PyPI features are always free to community groups) and has begun bringing in monthly income. We've also been seeking out grant opportunities where we find good fits with our mission.... We currently have more than six months of runway (as opposed to our preferred 12 months+ of runway), so the PSF is not at immediate risk of having to make more dramatic changes, but we are on track to face difficult decisions if the situation doesn't shift in the next year. Based on all of this, the PSF has been making changes and working on multiple fronts to combat losses and work to ensure financial sustainability, in order to continue protecting and serving the community in the long term. Some of these changes and efforts include: — Pursuing new sponsors, specifically in the AI industry and the security sector — Increasing sponsorship package pricing to match inflation — Making adjustments to reduce PyCon US expenses — Pursuing funding opportunities in the US and Europe — Working with other organizations to raise awareness — Strategic planning, to ensure we are maximizing our impact for the community while cultivating mission-aligned revenue channels The PSF's end-of-year fundraiser effort is usually run by staff based on their capacity, but this year we have assembled a fundraising team that includes Board members to put some more "oomph" behind the campaign. We'll be doing our regular fundraising activities; we'll also be creating a unique webpage, piloting temporary and VERY visible pop-ups to python.org and PyPI.org, and telling more stories from our Grants Program recipients... Keep your eyes on the PSF Blog, the PSF category on Discuss, and our social media accounts for updates and information as we kick off the fundraiser this month. Your boosts of our posts and your personal shares of "why I support the PSF" stories will make all the difference in our end-of-year fundraiser. If this post has you all fired up to personally support the future of Python and the PSF right now, we always welcome new PSF Supporting Members and donations.

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EditorDavid