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He Was Expected To Get Alzheimer's 25 Years Ago. Why Hasn't He?

3 months ago
Doug Whitney carries a genetic mutation that guaranteed he would develop Alzheimer's disease in his late forties or early fifties. His mother and nine of her thirteen siblings died from the disease. His oldest brother died at 45. The mutation has decimated his family for generations. Whitney is now 76 and remains cognitively healthy. The New York Times has a fascinating long read on Whitney and things happening around him. Scientists at Washington University School of Medicine in St. Louis have studied Whitney for 14 years. They extract his cerebrospinal fluid and conduct brain scans during his periodic visits from Washington State. His brain contains heavy amyloid deposits but almost no tau tangles in regions associated with dementia. Tau accumulation correlates directly with cognitive decline. Whitney accumulated tau only in his left occipital lobe, an area that does not play a major role in Alzheimer's. Researchers identified several possibly protective factors in Whitney's biology. His immune system produces a lower inflammatory response than other mutation carriers. He has unusually high levels of heat shock proteins, which prevent proteins from misfolding. Scientists believe his decade working in Navy engine rooms at temperatures reaching 110 degrees may have driven this accumulation. He also carries three gene variants his afflicted relatives lack. His son Brian inherited the mutation and remains asymptomatic at 43. Brian received anti-amyloid drugs in clinical trials. Researchers published their findings on Whitney in Nature Medicine. They described the study as a call for other scientists to help solve the case.

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Amazon's Quick Suite is like agentic AI training wheels for enterprises

3 months ago
Slow down there Andy; you wouldn't want to bump into any hallucinations

Despite ongoing concerns over the accuracy, reliability, and trustworthiness of AI in the enterprise, Amazon believes that if it can just make building agents easier for the average worker, they'll be automating the boring parts of their job in no time.…

Tobias Mann

Windows Product Activation Creator Reveals Truth Behind XP's Most Notorious Product Key

3 months ago
Dave W. Plummer, the Microsoft developer who created Task Manager and helped build Windows Product Activation, has revealed the origins of Windows XP's most notorious product key. The alphanumeric string FCKGW-RHQQ2-YXRKT-8TG6W-2B7Q8 was not cracked through clever hacking but leaked as a legitimate volume licensing key five weeks before XP's October 2001 release. A warez group distributed the key alongside special corporate installation media. Windows Product Activation generated hardware IDs from system components and sent them to Microsoft for validation. The leaked volume licensing key bypassed this entirely. The system recognized it as corporate licensing and skipped phone-home activation. Users could install XP without activation prompts or 30-day timers. Microsoft later blacklisted the key.

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Google rearranges Agentspace into Gemini Enterprise

3 months ago
A new spin on workflow automation as Chocolate Factory tries to displace Microsoft as the enterprise go-to

Google on Thursday announced the launch of Gemini Enterprise, a platform for automating business workflows using the company's Gemini family of machine learning models.…

Thomas Claburn

Crims had 3-month head start on defenders in Oracle EBS invasion

3 months ago
The miscreants started their attack all the way back on July 10

The raid on Oracle E-Business Suite (EBS) likely began as early as July - about three months before any public detections - with extortionists compromising "dozens" of organizations, a Google investigation has determined.…

Jessica Lyons

Internet Archive Ordered To Block Books in Belgium After Talks With Publishers Fail

3 months ago
The Internet Archive must block access to books in its Open Library project for Belgian users after negotiations with publishers failed. A Brussels Business Court issued a site-blocking order in July targeting several shadow libraries and the Internet Archive. A Belgian government department paused the order for the U.S. nonprofit and urged both parties to negotiate. The talks over recent weeks were unsuccessful. The Department for Combating Infringements of Copyright concluded last week that the Internet Archive hosts the contested books and has the ability to render them inaccessible. Publishers must supply a list of books to be blocked. The nonprofit then has 20 calendar days to implement the measures and prevent future digital lending of those works in Belgium. The order includes a one-time penalty of $578,000 for non-compliance and remains in place until July 16 next year. The Internet Archive operates Open Library by purchasing physical copies and digitizing them to lend out one at a time. Publishers previously won a U.S. federal court case against the project.

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