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Researchers Develop New Tool To Measure Biological Age

2 months ago
Stanford researchers have developed a blood-based AI tool that calculates the biological age of individual organs to reveal early signs of aging-related disease. The Mercury News reports: The tool, unveiled in Nature Medicine Wednesday, was developed by a research team spearheaded by Tony Wyss-Coray. Wyss-Coray, a Stanford Medicine professor who has spent almost 15 years fixated on the study of aging, said that the tool could "change our approach to health care." Scouring a single draw of blood for thousands of proteins, the tool works by first comparing the levels of these proteins with their average levels at a given age. An artificial intelligence algorithm then uses these gaps to derive a "biological age" for each organ. To test the accuracy of these "biological ages," the researchers processed data for 45,000 people from the UK Biobank, a database that has kept detailed health information from over half a million British citizens for the last 17 years. When they analyzed the data, the researchers found a clear trend for all 11 organs they studied; biologically older organs were significantly more likely to develop aging-related diseases than younger ones. For instance, those with older hearts were at much higher risk for atrial fibrillation or heart failure, while those with older lungs were much more likely to develop chronic obstructive pulmonary disease. But the brain's biological age, Wyss-Coray said, was "particularly important in determining or predicting how long you're going to live." "If you have a very young brain, those people live the longest," he said. "If you have a very old brain, those people are going to die the soonest out of all the organs we looked at." Indeed, for a given chronological age, those with "extremely aged brains" -- the 7% whose brains scored the highest on biological age -- were over 12 times more likely to develop Alzheimer's disease over the next decade than those with "extremely youthful brains" -- the 7% whose brains inhabited the other end of the spectrum. Wyss-Coray's team also found several factors -- smoking, alcohol, poverty, insomnia and processed meat consumption -- were directly correlated with biologically aged organs. Poultry consumption, vigorous exercise, and oily fish consumption were among the factors correlated with biologically youthful organs. Supplements like glucosamine and estrogen replacements also seemed to have "protective effects," Wyss-Coray said. [...] The test ... would cost $200 once it could be operated at scale.

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Russian Basketball Player Arrested For Alleged Role In Ransomware Attacks

2 months ago
joshuark writes: A Russian basketball player, Daniil Kasatkin, was arrested on June 21 in France at the request of the United States as he allegedly is part of a network of hackers. Daniil Kasatkin, aged 26, is accused by the United States of negotiating the payment of ransoms to this hacker network, which he denies. He has been studied in the United States, and is the subject of a U.S. arrest warrant for "conspiracy to commit computer fraud" and "computer fraud conspiracy." His lawyer alleges that Kasatkin is not guilty of these crimes and that they are instead linked to a second-hand computer that he purchased. "He bought a second-hand computer. He did absolutely nothing. He's stunned," his lawyer, Freric Belot, told the media. "He's useless with computers and can't even install an application. He didn't touch anything on the computer: it was either hacked, or the hacker sold it to him to act under the cover of another person." The report notes that Kasatkin briefly played NCAA basketball at Penn State before returning to Russia in 2019. He also appeared in 172 games with MBA-MAI before he left the team.

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iFixit: the Switch 2 Pro is a 'Piss-Poor Excuse For a Controller'

2 months ago
iFixit has harsh words for Nintendo's $85 Switch 2 Pro controller, calling it a "piss-poor excuse for a controller" due to its difficult repairability, use of outdated drift-prone joysticks, and poor internal accessibility. The Verge reports: Opening the controller requires you to first forcefully remove a faceplate held in place by adhesive tape before a single screw is visible. But you'll need to extract several other parts and components, including the controller's mainboard, before its battery is even accessible. As previously revealed, the Pro 2 is still using older potentiometer-based joysticks that are prone to developing drift over time. They do feature a modular design that will potentially make them easier to swap with third-party Hall effect or TMR replacements, but reassembling the controller after that DIY upgrade will require you to replace all the adhesive tape you destroyed during disassembly. You can watch the full teardown on YouTube.

Read more of this story at Slashdot.

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