Major retailer opening THIS WEEKEND at Lakeside Shopping Centre
Lakeside Shopping Centre has announced major jewellery retailer Ernest Jones will be opening this weekend.
Tories swipe at Andy Burnham for being 'too chicken' to sign off new North Sea drilling in wake of Britain's heatwave summer - even though 'he knows it's right' to give go-ahead
Claire Coutinho, the shadow energy secretary, hit out at the Prime Minister amid claims he has pushed a decision on the Rosebank and Jackdaw projects into the autumn.
Fury as UK health chiefs won't disclose source of 'imported' deadly eggs - as major salmonella outbreak kills one and makes 200 sick
Scientists and industry leaders said that the Government may need to impose stricter importation rules amid the current spread of Salmonella, which has killed one and left more than 200 ill.
ICE boss to agents: Leave the Meta spy glasses at home
'Personally owned body-worn cameras are prohibited,' ICE tells The Reg. Because the last thing DHS needs is more proof of misconduct
'Landmark moment' as vaccine stops deadly skin cancer returning in striking trial
A new personalised vaccine could halve the risk of skin cancer returning in high-risk patients, a large trial has found.
Woke Canadian town officially recognizes TREES as living beings with rights: 'Our biggest ally'
A small town in Quebec has become the first public entity in North America to sign onto the Universal Declaration of Tree Rights, which argues that a tree is 'a sentient living being.'
Moderna, Merck Say mRNA Vaccine Prevents Melanoma From Returning
Moderna and Merck say their personalized mRNA melanoma vaccine significantly reduced both cancer recurrence and spread in a late-stage trial. The treatment could reach patients as soon as next year if regulators approve it. Reuters reports: Moderna developed the vaccine with Merck and tested it together with immunotherapy drug Keytruda, a widely used treatment for melanoma. [...] This is the first positive late-stage trial result for an mRNA cancer vaccine, which trains a patient's immune system to fight tumors by targeting specific mutations in those cells and the first such study to show that adding a treatment to Keytruda worked better than that therapy alone. Similar approaches are being tested against lung, breast and pancreatic cancers.
[...] The cancer treatment combines Merck's Keytruda with a made-to-order mRNA vaccine from Moderna that is based on an analysis of mutations found in the patients' own tumors. The trial enrolled 1,137 high-risk patients with stage IIB-IV melanoma that had been surgically removed. Volunteers were randomized to receive up to nine doses of Keytruda plus the personalized vaccine or Keytruda alone for about one year. The companies said no new safety signals have emerged in the trial. In January, the companies announced results of a mid-stage trial of the treatment showing that it reduced the risk of recurrence or death by 49% after five years. Karen Knudsen, CEO of the Parker Institute for Cancer Immunotherapy, said the Moderna results could signal a new era for treating solid-tumor cancers. "The positive hit here leads us into truly this next phase in immunotherapy," Knudsen said. "This is an auspicious start -- this is where things begin."
Moderna shares more than doubled on the news, adding about $30 billion to its market value.
Read more of this story at Slashdot.
Millions taking common blood pressure medication at risk of deadly kidney disease, top experts warn
A study found that type 2 diabetes patients taking dihydropyridine calcium-channel blockers (DCCBs) were at a 33 per cent higher risk of complications like kidney disease.
Largest great white shark ever recorded in Atlantic reveals new location after racing up US East Coast
The largest male great white shark ever recorded in the Atlantic has suddenly reappeared after prowling the US East Coast.
Family who drowned off Sussex beach were a Palestinian refugee, his wife and daughter - as video shows moment lifeboat battled heavy seas in desperate search for victims
Hassan El-Khawas, 55, his partner Zeina Alayn, 37, and their teenage daughter Sara, 14, all drowned while swimming in Shoreham-by-Sea, West Sussex, at around 3pm yesterday.
Camilla is ready come rain or come shine! Queen beams despite the grey skies at York races
Camilla, 79, beamed as she shielded herself from the slight drizzle on the first day of the Ebor Festival at York Racecourse.
Number of foreign offenders still living freely in Britain despite being earmarked for deportation surges nearly 10 per cent to record high since Labour came to power - with early release scheme set to fuel crisis, experts warn
Just over 18,000 foreign offenders subject to deportation were living freely within the community after serving their sentence when Labour won the election in July 2024.
A12 CLOSED after crash causing severe delays for drivers
A section of the A12 is closed near Boreham after a crash, causing severe delays for drivers.
A12 CLOSED after crash causing severe delays for drivers
A section of the A12 is closed near Boreham after a crash, causing severe delays for drivers.
One in three children talk or play with strangers online with half saying bypassing parental controls is 'easy'
A survey by the Information Commissioner's Office found that 36 per cent of youngsters interact with people they only know online - or not at all.
X's Algorithm Feeds Off Ragebait and Impacts Democrats More, Study Finds
An anonymous reader quotes a report from 404 Media: X's algorithm learns what you hate and shows you more of it, according to a new study just published in the Proceedings of the National Academy of Sciences (PNAS). The paper, titled Value misalignment of X's feed algorithm is a reflection of value tensions in engagement, found that the site's algorithm prioritized engagement above all else when it generated a user's For You Page. It also showed that X serves more ragebait to people who say they are Democrats, although the exact reason for that is unclear. "In 2026 that's maybe not the most surprising headline ever," Ziv Epstein, a postdoctoral researcher at Stanford University, and co-author of the paper, told 404 Media. "So we actually dug in a little deeper to figure out why this is actually happening, and it turns out that X's feed algorithm, like a lot of these social media algorithms, is optimized for engagement [but] it turns out that not all types of engagement are considered equally."
The researchers found that X's algorithm can push users toward content that conflicts with their stated values, especially when they reply to posts that anger or provoke them. Although replies accounted for just 6.8% of interactions, they appeared to carry disproportionate weight: "It's this feedback loop of outrage baiting. The algorithm learns that you get outraged and then continues to serve more content in that direction," said Epstein.
It's unclear why X seems to serve ragebait to Democrats more often than Republicans. 404 Media speculates that it may be because there's more rightwing content on X overall or that Democrats tend to engage with posts they disagree with more often. "There might be some kind of differential effects on information diets there, or it might be something more psychological about how different you know partisan identities are triggering different kinds of actions and reactions, but ultimately I don't want to speculate too much," said Epstein.
X's former product chief Nikita Bier confirmed that the site had been set to favor replies. "This is no longer true," Bier said in a post on X. "The largest contributor of seeing ragebait was the reply predictor and we were aware that angry replies were causing people to see more of that content. So last month, we gave the reply predictor a 15x boost if it's a friend's post -- and it reduced ragebait by [an] order of magnitude."
Read more of this story at Slashdot.
Montana Brown reveals 'controversial' decision to give her children whole nuts from the age of eight months in her latest 'rage-baiting' post as she defies NHS guidance
Montana Brown has shared her most recent 'controversial' decision to feed her children nuts - despite it going against the NHS guidelines.
Syrian man, 27, charged with sexually assaulting two teenage girls in hotel
Police officers rushed to the hotel in Kenilworth, Warwickshire, on Monday evening after receiving reports of a sex attack.
Referees chief Howard Webb slams FIFA over Folarin Balogun red card scandal
MIKE KEEGAN: England's head of officiating said he was 'really troubled' by the saga, which marred the summer's showpiece.
My mother hired a paedophile to be my babysitter. From the age of six, he brutally raped me for two years before being jailed. I thought my nightmare was over... and then I found him sitting at our kitchen table
When we meet in a pub near her home, I notice Della Wright scanning the room cautiously before taking a seat. It's a small gesture, easily missed, but it seems at odds with her authoritative demeanour...