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Keir Starmer played down alarm about whether US stands by Article 5 of the military alliance after Mr Trump said the meaning 'depends on your definition'.

The owners said it had "been a pleasure" to be part of the community

This once down-market industrial hub may seem an odd choice for A-listers more accustomed to the glitz and glamour of Beverly Hills.

Keir Starmer sounded defiance about 'noises off' - and insisted he will not quit - as he looks down the barrel of a huge rebellion on the flagship legislation.

From ground zero to miles away a brutal animation shows the horror a nuclear detonation would have on the human body, including blindness, radiation burns and total vapourisation.

A groundbreaking stem cell treatment developed by Vertex Pharmaceuticals has allowed 10 out of 12 patients with severe type 1 diabetes to stop insulin therapy after one year. While the trial included some side effects and two unrelated deaths, the results mark a major step forward and have progressed to phase 3 clinical testing. ScienceAlert reports: The pancreas's islet cells are responsible for maintaining most of our bodies' insulin levels. Donor transplants of healthy versions of these cells have shown promise in treating type 1 diabetes in the past, but multiple donors are required, and donors are rare. So University of Toronto surgeon Trevor Reichman and colleagues infused 12 patients with islet cells derived from human stem cells in a treatment known as zimislecel. The patients also received immunosuppressive treatment before and after their zimislecel infusion. The islets not only produced insulin inside their bodies, but they did so at safe levels, reducing the patients' dependence on costly doses of insulin. "These findings showed that zimislecel islet cells were functional and self-regulated appropriately," the researchers write in their paper. The mild to moderate side-effects, including decreased kidney function and the anticipated drop in immune cells, were all linked with the immunosuppressive therapy. Sadly, two additional participants died during the trial; one from an infection arising from surgery and the other from complications due to an unrelated condition. As there were no serious adverse events attributed to the new islet cell therapy, the clinical trials are have progressed into phase 3. "These findings provide evidence that pancreatic islets can be effectively produced from pluripotent stem cells and used to treat type 1 diabetes," Reichman and team conclude. The research has been published in the journal NEJM.

Read more of this story at Slashdot.

Plane passengers are often amused by the quirks of flying - like crisp packets puffing up due to cabin pressure - but Brookfield Aviation has highlighted a phenomenon that some would find a little unsettling

Convicted thug Dougie Joyce, from Manchester, appeared alongside the former Prime Minister in a clip filmed as she made a visit to Scunthorpe United's ground.

He had entered cannabis-induced psychosis before going on the violent spree

Rachel Stanton, 32, admitted to wilful misconduct in public office after she entered a relationship with Edwin Poole while he was serving a 10-and-a-half-year sentence.

REPORTS of an incident on the A12 northbound have been acknowledged.

The fashion giant has revealed the full list of 33 stores set to be axed under sweeping plans which could put thousands of jobs on the line.

Step-in host Robert Rinder, 47, presented the programme as he was joined by the likes of journalist Carole, 70, and Radzi Chinyanganya, 38, in the studio.

When it comes to simple accessories that pack a huge fashion punch, sunglasses are the ultimate go-to.

The daughter of Jeremy Clarkson, a regular on Lorraine, told presenters how a group of men in a van leered at her while walking her baby in a pram in London.

He has since resigned from Essex Police

PC Hannah Briggs, of Hampshire police, was called to the murder scene of the youngster who had been savagely beaten before being set on fire and dumped.

The first hand-built example has already been delivered to an extremely well-known face... and body.

Chinese crew built 1,000+ device network that runs on home devices then targets critical infrastructure

A stealthy, ongoing campaign to gain long-term access to networks bears all the markings of intrusions conducted by China’s ‘Typhoon’ crews and has infected at least 1,000 devices, primarily in the US and South East, according to SecurityScorecard's Strike threat intel analysts. And it uses a phony certificate purportedly signed by the Los Angeles police department to try and gain access to critical infrastructure.…

Na'im Payman snapped up the Grade II-listed Royal Hotel in Kettering, Northamptonshire back in 2020 for £2.2 million.