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Switching Off One Crucial Protein Appears to Reverse Brain Aging in Mice

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2 months 1 week ago
A research team just discovered older mice have more of the protein FTL1 in their hippocampus, reports ScienceAlert. The hippocampus is the region of the brain involved in memory and learning. And the researchers' paper says their new data raises "the exciting possibility that the beneficial effects of targeting neuronal ferritin light chain 1 (FTL1) at old age may extend more broadly, beyond cognitive aging, to neurodegenerative disease conditions in older people." FTL1 is known to be related to storing iron in the body, but hasn't come up in relation to brain aging before... To test its involvement after their initial findings, the researchers used genetic editing to overexpress the protein in young mice, and reduce its level in old mice. The results were clear: the younger mice showed signs of impaired memory and learning abilities, as if they were getting old before their time, while in the older mice there were signs of restored cognitive function — some of the brain aging was effectively reversed... "It is truly a reversal of impairments," says biomedical scientist Saul Villeda, from the University of California, San Francisco. "It's much more than merely delaying or preventing symptoms." Further tests on cells in petri dishes showed how FTL1 stopped neurons from growing properly, with neural wires lacking the branching structures that typically provide links between nerve cells and improve brain connectivity... "We're seeing more opportunities to alleviate the worst consequences of old age," says Villeda. "It's a hopeful time to be working on the biology of aging." The research was led by a team from the University of California, San Francisco — and published in Nature Aging..

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