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Researchers are developing techniques to genetically modify cancer-fighting immune cells directly inside patients rather than in expensive laboratory facilities, potentially making CAR-T therapy accessible to far more people. Current CAR-T treatments require removing a patient's T cells, shipping them to specialized facilities for genetic engineering, then returning them weeks later at costs around $500,000 per dose. The new "in vivo" approaches use viral vectors or RNA-loaded nanoparticles to deliver genetic instructions directly to T cells circulating in the bloodstream, which could reduce costs by an order of magnitude. Companies including Capstan Therapeutics, co-founded by Nobel laureates, and AstraZeneca-backed EsoBiotec have launched early human trials. While only about 200 US centers currently offer traditional CAR-T therapy, the approach could make the powerful treatment available on demand like conventional drugs.

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As Jay's mother Debbie Duncan, 56, pleaded for information, MailOnline examines eight key questions which remain unanswered.

The influencer, 26, was plunged into grief after the death of her boyfriend Liam Payne at aged 31 last October.

A new profanity-littered study reveals that Brits are the second-most prolific swearers in the world.

To the dread of dietitians across the planet, there's an even more extreme version of 'intermittent fasting' being taken up by those wanting to lose weight-the OMAD diet.

The singer, 55, ensured all eyes were on her as she slipped into a midnight blue jumosuit that showed off her famous derriere.

Nigel Farage trolled that Keir Starmer is 'terrified' of the threat from the insurgents as he committed to scrap the two-child benefit cap and fully restore winter fuel payments.

Customers are urged to stop using the product and return them to your nearest from for a full refund.

Essex Police are urging the public to come forward with information

The waterfront shacks had fallen into a state of disrepair and were due to be removed prior to being set alight.

The Congestion Charge will increase from £15 to £18 from 2 January 2026 - and could rise annually thereafter under plans set out by TfL.

German sportswear giant Adidas disclosed a data breach after attackers hacked a customer service provider and stole some customers' data. From a report: "adidas recently became aware that an unauthorized external party obtained certain consumer data through a third-party customer service provider," the company said. "We immediately took steps to contain the incident and launched a comprehensive investigation, collaborating with leading information security experts." Adidas added that the stolen information did not include the affected customers' payment-related information or passwords, as the threat actors behind the breach only gained access to contact. The company has also notified the relevant authorities regarding this security incident and will alert those affected by the data breach.

Read more of this story at Slashdot.

Controversy was already swirling over whether the run should have been considered as a legitimate world record attempt in the first place well before William Goodge reached the finish line

Russia's foreign minister Sergey Lavrov described Trump as a 'man who wants results' as he announced the breakthrough at an event in Turkey on Tuesday.

Women took to social media with confessions of hitting their husbands as a clip of Brigitte Macron shoving her husband French President Emmanuel Macron went viral.

Plans include new neighbourhood centre, 'significant' public open space and pedestrian and cycle routes 'enhancing connectivity'

The couple visited the Eleven Madison Park as they tucked into the ten course tasting menu priced at $365-per-head.

Video footage has captured the horrifying moment a three-year-old girl was struck by an e-bike rider after running into a bike lane in Brooklyn.

Martyn Sadler, 38, Jennie Logan, 30, and businessman David Chester, 57, were killed after a fire engulfed Bicester Motion - a former RAF base - on May 15.

A dangerous new trend that sees people using a freezing cold device to mark their skin and change hair colour raises your cancer risk, warns doctors.