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Old Blood Cells Have Been Transformed Into Brain Stem Cells That Get Younger

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1 week 6 days ago
"Scientists have transformed old blood cells into young brain stem cells, which continued to grow younger as they grew older," reports ScienceAlert: Cellular transformations can be done in two main ways. The first, more circuitous route turns a specific cell back into a pluripotent stem cell, or an embryonic "blank slate," and then into a different cell type. The second method involves a "direct conversion," which skips the middle stage and directly transforms a cell into a different type. "Using this method, we have directly converted red blood cell precursors into neural stem cells," summarizes Oliver Brüstle, the director of the Institute of Reconstructive Neurobiology at the University Hospital of Bonn... The researchers used a virus to deliver two transcription factors, or proteins that attach to DNA to regulate gene activity, to get the cells to change their types. Then they used two genome-bloodhounding methods — DNA methylation measures and RNA sequencing — to track the resultant anti-aging effects and genetic behavior. By the 12th day after the viral "infection," the cells started showing their new identity, ditching their blood-like proteins and replacing them with the expression of neural-like proteins instead. Initially, the epigenetic age (the DNA changes accumulated over time) of the EPCs was highly correlated with the chronological age of their donors [but] the neuronal stem cells kept getting younger as they got older... Over the following 50 to 100 days, they kept de-aging, eventually reaching about 5 percent of the donor age, with the majority of epigenetic age-related traits resetting by around 50 days of the conversion process... In effect, the converted cells became 60 years younger in 50 days, the researchers note in their official statement. The researchers, from the University Hospital of Bonn and the University of Bonn, in Germany, described their methods in the journal Aging Cell.

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