Desperate search is launched for missing tourist Harrison Edward Nada Kontounas in Bali after he disappeared at a beach
A British foreign national was swimming with two friends at a Bali beach on Wednesday afternoon when a strong current dragged him away.
Inside stateless ISIS bride Shamima Begum's life in hellhole refugee camp as she dreams of return to Britain
Begum was seen for the first time in years after storming out of an interview at the al-Roj camp in Syria which has been criticised by the Red Cross for being 'grim' and 'extremely volatile.'
Wicked: For Good's final trailer sees Ariana Grande and Cynthia Erivo's characters face off in dramatic showdown as fans are treated to teaser of new music while Dorothy arrives in Oz
The sequel sees the return of Cynthia Erivo as Elphaba, the Wicked Witch of the West, and Ariana Grande as Glinda, the Good Witch of the North.
High school of football player who fractured rival's spine takes 'strong and decisive action' after senseless attack
A high school in Michigan has punished one of their own junior varsity players who senselessly injured a much smaller opponent by jumping on top of them and fracturing their spine.
Donald Trump must face criminal proceedings for deadly strikes carried out on drug smuggler boats in the Caribbean, UN is told
Colombia's leader condemned three attacks this month, which were defended as operations against drug traffickers. He accused the former president of criminalising poverty and migration.
Strictly star Thomas Skinner's firm still owes £50k Covid loan to taxpayer despite boasting about turning over millions of pounds in the pandemic
The Essex businessman, who found fame after appearing on Lord Sugar 's The Apprentice, has become the most controversial signing on Strictly this year.
Kim Kardashian stuns onlookers in bizarre see-through catsuit as she arrives at NikeSKIMS launch event in NYC
Kim Kardashian had all eyes on her as she arrived to her Skims and Nike store launch event on Wednesday in New York City.
Here's where you can watch Taylor Swift's world exclusive new album film in Essex
Fans of Taylor Swift can see behind the scenes footage and her new music video in the world premiere at cinemas in Essex.
Here's where you can watch Taylor Swift's world exclusive new album film in Essex
Fans of Taylor Swift can see behind the scenes footage and her new music video in the world premiere at cinemas in Essex.
Britain's gangster pub guide: Where machete attacks and mob hits meet lap dances and pints of lager - the favoured haunts that have seen it all revealed
These are the pubs with a connection to some of Britain's most feared gangsters.
Police find brutal weapon in grinning Essex crook's bedroom
The criminal was involved in county lines drug dealing. The zombie knife was found hidden behind a television in his bedroom.
Here's what's in store for YOUR sign this month as Libra season promises 'beauty and harmony' - from self-care deprived Taurus to emotional Pisces
If the autumnal British weather has been bringing you down, worry for - for the stars promise 'beauty and harmony' over the next few weeks.
Mother of Dallas ICE shooter Joshua Jahn is hardline liberal who raged against gun rights
Sharon Jahn, the mother of 29-year-old Joshua Jahn, kept an active Facebook page where she followed everyone from Kamala Harris to an account representing Democratic Socialists.
The real cost of climate change: Global warming could make the average person 24% poorer by 2100, scientists warn
By 2100, today's developed countries could be pushed further into an unprecedented type of poverty, a study from University of Cambridge scientists suggests.
Now even DOGS are being told to go vegan! Plant-based pet foods are better for the environment than meaty options, scientists claim
Experts from the University of Nottingham claim that pet owners should consider putting their dogs on vegan diets - because they're better for the environment.
The sweetest slice of Pi: Raspberry Pi 500+ sports mechanical keys, 16GB, and built-in SSD
Big performance on offer, but be prepared to spend $200
HANDS ON Raspberry Pi has unveiled a fully loaded version of its computer-in-a-keyboard, featuring oodles of RAM, an SSD, and a clicky, mechanical keyboard. However, you'll pay a relative premium for these features.…
Brooklyn Beckham suffers HUMILIATION during Ryder Cup celebrity match as he's mocked by fans
Brooklyn Beckham was completely humiliated during the Ryder Cup celebrity match and it wasn't because his team was losing. Fans mocked him throughout the game.
Experimental Gene Therapy Found To Slow Huntington's Disease Progression
Doctors report the first successful treatment for Huntington's disease using a new type of gene therapy given during 12 to 18 hours of delicate brain surgery. The BBC reports: An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients. It means the decline you would normally expect in one year would take four years after treatment, giving patients decades of "good quality life", Prof Sarah Tabrizi told BBC News. The first symptoms of Huntington's disease tend to appear in your 30s or 40s and is normally fatal within two decades -- opening the possibility that earlier treatment could prevent symptoms from ever emerging. None of the patients who have been treated are being identified, but one was medically retired and has returned to work. Others in the trial are still walking despite being expected to need a wheelchair. Treatment is likely to be very expensive. However, this is a moment of real hope in a disease that hits people in their prime and devastates families. [...]
It starts with a safe virus that has been altered to contain a specially designed sequence of DNA. This is infused deep into the brain using real-time MRI scanning to guide a microcatheter to two brain regions - the caudate nucleus and the putamen. This takes 12 to 18 hours of neurosurgery. The virus then acts like a microscopic postman -- delivering the new piece of DNA inside brain cells, where it becomes active. This turns the neurons into a factory for making the therapy to avert their own death. The cells produce a small fragment of genetic material (called microRNA) that is designed to intercept and disable the instructions (called messenger RNA) being sent from the cells' DNA for building mutant huntingtin. This results in lower levels of mutant huntingtin in the brain. [...]
The data showed that three years after surgery there was an average 75% slowing of the disease based on a measure which combines cognition, motor function and the ability to manage in daily life. The data also shows the treatment is saving brain cells. Levels of neurofilaments in spinal fluid -- a clear sign of brain cells dying -- should have increased by a third if the disease continued to progress, but was actually lower than at the start of the trial.
Read more of this story at Slashdot.
Plans to fine bad drivers and parents flouting school street bans in Southend
Southend Council is setting up more cameras to enforce moving traffic restrictions
Authentically Inauthentic: Jan Moir delivers an honest take on Meghan Markle's jammy brand in Palace Reacts
Daily Mail columnist Jan Moir pulls no punches when giving her verdict on Duchess of Sussex Meghan's lifestyle brand rollout.