The two titanic issues that will define - or destroy - the Starmer Government: TOM HARRIS
TOM HARRIS: After just a year in government, it seems premature to characterise the Prime Minister's selection as the 'last roll of the dice'.
I lived the life as Jennifer Lopez for the week at the £3K-a-night Regnum The Crown hotel in Turkey and here is everything you need to know from her favourite cocktail to luxury private butler service
When I was offered the chance to jet off to the luxurious Regnum The Crown hotel in Turkey to 'live the life as Jennifer Lopez for the week', how could I possible refuse.
The real life 'Dexter': Brazilian serial killer slaughtered over 100 people - but claims he only targeted rapists, drug dealers and murderers
Brazilian serial killer Pedro Rodrigues Filho, who is said to have killed more than 100 people, is believed to have only targeted criminals like murderers and rapists.
Why you may need HRT even if you DON'T have hot flushes... these are the 30 symptoms it can solve, from joint pain to headaches and more
The woman in my clinic looks vaguely irritated. The 54-year-old mother-of-three - let's call her Sarah - has come to see me about the bladder infections that have been plaguing her for months.
Couple hit back at 'tasteless' critics after their £650k home is called 'truly horrible'... but can you spot why?
Drew Harriman and his partner spent hundreds of thousands of pounds extending conserving and re-roofing the Georgian house - highlighting its classical features.
REVEALED: How creatine could destroy your organs... Millions believe trendy supplement helps their bones and brains - but now doctors fear deadly new side effects
Creatine, which is produced naturally by the liver, pancreas and kidneys, helps cells produce energy, but it has long been taken in higher doses by athletes and bodybuilders.
Villagers force travel firm who rebranded Welsh manor with an English name to revert back to its original title
Plas Bodegroes (pictured), an 18th-century house in the village of Efailnewydd, Gwynedd, was marketed by Big House Experience (BHE) as Bromfield Hall.
The dark side of Mark Bellingham: OLIVER HOLT reveals Jude's dad's jaw-dropping tirades behind closed doors, how he made his son a 'special case' and how it has split the England dressing room
It was two weeks ago, at a stadium in Hamburg, when an issue that haunts the FA's stewardship of the England football team, burst into the public domain for the first time.
The Essex tower once run by an actress and used as a lookout in wars
The tower was used as a lighthouse, and as a tea house before being turned into a museum
Sobbing Japan PM Shigeru Ishiba to resign amid fallout from disastrous election
NHK said Shigeru Ishiba made the decision to avoid a divide within the party, while the Asahi Shimbun newspaper said he was unable to withstand the mounting calls for his resignation.
Switching Off One Crucial Protein Appears to Reverse Brain Aging in Mice
A research team just discovered older mice have more of the protein FTL1 in their hippocampus, reports ScienceAlert.
The hippocampus is the region of the brain involved in memory and learning. And the researchers' paper says their new data raises "the exciting possibility that the beneficial effects of targeting neuronal ferritin light chain 1 (FTL1) at old age may extend more broadly, beyond cognitive aging, to neurodegenerative disease conditions in older people."
FTL1 is known to be related to storing iron in the body, but hasn't come up in relation to brain aging before... To test its involvement after their initial findings, the researchers used genetic editing to overexpress the protein in young mice, and reduce its level in old mice. The results were clear: the younger mice showed signs of impaired memory and learning abilities, as if they were getting old before their time, while in the older mice there were signs of restored cognitive function — some of the brain aging was effectively reversed...
"It is truly a reversal of impairments," says biomedical scientist Saul Villeda, from the University of California, San Francisco. "It's much more than merely delaying or preventing symptoms." Further tests on cells in petri dishes showed how FTL1 stopped neurons from growing properly, with neural wires lacking the branching structures that typically provide links between nerve cells and improve brain connectivity...
"We're seeing more opportunities to alleviate the worst consequences of old age," says Villeda. "It's a hopeful time to be working on the biology of aging."
The research was led by a team from the University of California, San Francisco — and published in Nature Aging..
Read more of this story at Slashdot.
Schoolgirl victim of the Southport stabbing brands killer Axel Rudakubana a coward and declares 'that's all he's ever going to be'
The teen was stabbed three times in her arm and back during the attack last July which claimed the lives of Alice da Silva Aguiar, nine, Bebe King, six, and Elsie Dot Stancombe, seven.
My adorable cockapoo Waffle was the perfect puppy - then he grew into 22kg beast with health issues that have cost me a fortune
Charlotte Fallowfield from Shrewsbury paid £800 for Waffle after finding him on a breeder listed online in 2019.
First Tube strike since 2023 begins as limited service runs today ahead of TOTAL shutdown at 6pm after union holds firm on pay increase demands
London Underground staff have started striking this morning over an RMT-led dispute over pay and conditions which will see the city grind to a halt over the coming week.
Essex landowners urged to cut back overgrown vegetation near roads and footpaths
Essex County Council is urging landowners to cut back overgrown vegetation near roads and footpaths.
Essex landowners urged to cut back overgrown vegetation near roads and footpaths
Essex County Council is urging landowners to cut back overgrown vegetation near roads and footpaths.
One in five people are now antisemitic, new polling claims, as Jewish community and allies prepare to march this afternoon
The findings showed that the number of people holding what would be considered entrenched anti-Semitic views has doubled in less than five years.
The 'unloved' Victorian 'ghost hotel' on the market for £5m after being left empty by millionaire family
The grand clock ticks away to the precise second on the outside of the majestic building but inside time stands still at almost abandoned Stoke Rochford Hall.
'Mature' actor says TV producers use 'insulting' stereotypes to portray older people on screen - as new reports suggests millions over the age of 55 feel 'left behind' by modern programmes
Chris Conil, 77, who has appeared as an extra in EastEnders , Silent Witness and The Bill, said they are often shown as 'grumpy, feeble or comic relief '.
Keep your cool! Ministers urge Brits to remain calm when their phones buzz at 3pm TODAY during latest test of national emergency alert system
Secretary of State Pat McFadden said he knows Brits will 'keep their cool' when their phones make a siren-like noise for 10 seconds, vibrate and show a message.