Skip to main content

'We Are Not Programmed to Die,' Says Nobel Laureate Venki Ramakrishnan

2 months 3 weeks ago
In a recent interview with Wired, Nobel laureate Venkatraman Ramakrishnan discusses his book Why We Die, in which he argues that death is not genetically programmed but rather a consequence of evolution favoring reproduction over longevity. Here are some of the most thought-provoking excerpts: WIRED: Professor Ramakrishnan, the crucial question in your book is why we die. But exactly what is death? Venki Ramakrishnan: By death, we mean the irreversible loss of the ability to function as a coherent individual. It is the result of the failure of a critical system or apparatus, for example, heart, brain, lung, or kidney failure. In this sense there is an apparent paradox: When our organism, as a whole, is alive, millions of cells within us are constantly dying, and we do not even realize it. On the other hand, at the time of death, most of the cells in our bodies are still alive, and entire organs are still functioning and can be donated to people in need of transplantation. But at that point the body has lost the ability to function as a whole. In this sense, it is therefore important to distinguish between cell death and death of the individual. Speaking of death and aging, you say in your most recent book that you "wanted to offer an objective look at our current understanding of the two phenomena." What was the biggest surprise or most deeply held belief that you had to reconsider while writing and researching this work? There have been several surprises, actually. One is that death, contrary to what one might think, is not programmed by our genes. Evolution does not care how long we live, but merely selects the ability to pass on our genes, a process known as "fitness" in evolutionary biology. Thus, the traits that are selected are those that help us survive childhood and reproduce. And it is these traits, later in life, that cause aging and decline. Another curious finding was the fact that aging is not simply due to wear and tear on cells. Wear and tear happens constantly in all living things, yet different species have very different lifespans. Instead, lifespan is the result of a balance between the expenditure of resources needed to keep the organism functioning and repairing it and those needed to make it grow, mature, and keep it healthy until it reproduces and nurtures offspring. Do you think there is an aspect of the biology of aging that is still deeply misunderstood by the general public? Certainly the indefinite extension of life. Although in principle there are no laws or constraints that prevent us from living much longer than we do currently, great longevity or "eternal youth" are still far off, and very significant obstacles to increasing our maximum life expectancy remain. We must also beware of the pseudoscience -- and business -- around the concepts of "anti-aging" or the "reversal of aging." These are often baseless concepts, unsupported by hard evidence, even though they may use language that sounds scientific. Unfortunately, we are all afraid of growing old and dying, so we are very sensitive to any claim that promises to help us avoid it. [...] What do you think are the social and ethical implications of our desire to live longer? Ever since we became aware of our mortality, we have desired to defeat aging and death. However, our individual desires may conflict with what is best for society. A society in which fertility rates are very low and lifespans are very high will be a stagnant society, with very slow generational turnover, and probably much less dynamic and creative. The Nobel Prize-winning South American novelist Mario Vargas Llosa, who recently passed away, expressed it best: "Old age on the one hand terrifies us, but when we feel anxious, it is important to remember how terrible it would be to live forever. If eternity were guaranteed, all the incentives and illusions of life would vanish. This thought can help us live old age in a better way."

Read more of this story at Slashdot.

BeauHD

Microsoft Confirms Classic Outlook CPU Usage Spikes, Offers No Fix

2 months 3 weeks ago
Microsoft has acknowledged that Classic Outlook can mysteriously transform into a system resource hog, causing CPU usage spikes between 30-50% and significantly increasing power consumption on both Windows 10 and 11 systems. Users first reported the issue in November 2024, but Microsoft only confirmed the problem this week, offering little resolution beyond stating that "the Outlook Team is investigating this issue." The company's sole workaround involves forcing a switch to the Semi-Annual Channel update through registry edits -- an approach many enterprise environments will likely avoid. Microsoft hasn't announced a definitive end date for Classic Outlook, but the company continues pushing users toward its New Outlook client despite its incomplete feature set.

Read more of this story at Slashdot.

msmash

Free Blue Screens of Death for Windows 11 24H2 users

2 months 3 weeks ago
Microsoft rewards those who patch early with bricks hurled through its operating system

Keeping with its rich history of updates that break Windows in unexpected ways, Microsoft has warned that two recent patches for Windows 11 24H2 are triggering blue screen crashes.…

Brandon Vigliarolo

Harvard's RoboBee Masters Landing, Paving Way For Agricultural Pollination

2 months 3 weeks ago
After more than a decade of development, Harvard's insect-sized flying robot, RoboBee, has successfully learned to land using dragonfly-inspired legs and improved flight controls. The researchers see RoboBee as a potential substitute for endangered bees, assisting in the pollination of plants. From a report: RoboBee is a micro flying robot that Harvard has been developing since 2013. As the name suggests, it is the size of a bee, capable of flying like a bee and hovering in mid-air. Its wings are 3 cm long and it weighs only 0.08 g. The weight was reduced by using light piezoelectric elements instead of motors. Piezoelectric elements change shape when an electric current flows through them. The researchers were able to make RoboBee flap its wings 120 times per second by turning the current on and off, which is similar to actual insects. While RoboBee exhibited flight capabilities comparable to those of a bee, the real problem was landing. Being too light and having short wings, it could not withstand the air turbulence generated during landing. It is easy to understand if you think about the strong winds generated when a helicopter approaches the ground. Christian Chan, a graduate student at Harvard who participated in the research, said, "Until now, it was a matter of shutting off the robot while it attempted to land and praying for a proper touchdown." To ensure RoboBee's safe landing, it was important to dissipate energy just before touchdown. Hyun Nak-Seung, a professor at Purdue University who participated in the development of RoboBee, explained, "For any flying object, the success of landing depends on minimizing speed just before impact and rapidly dissipating energy afterward. Even for tiny flapping like RoboBee's, the ground effect cannot be ignored, and after landing, the risk of bouncing or rolling makes the situation more complex." The findings have been published in the journal Science Robotics.

Read more of this story at Slashdot.

BeauHD

Researchers Grow Record-sized Lab Meat

2 months 3 weeks ago
Researchers at the University of Tokyo have created what they believe is the largest single piece of lab-grown meat to date: a chicken nugget-sized chunk measuring 7 centimeters long, 4 centimeters wide, and 2.25 centimeters thick, weighing 11 grams. The breakthrough, reported today in Trends in Biotechnology, uses an artificial circulatory system to overcome a fundamental limitation in cultured meat production. The team, led by biohybrid system engineer Shoji Takeuchi, grew cells around a network of semipermeable hollow fibers -- similar to those used in water filters and dialysis machines -- that deliver nutrients and oxygen throughout the tissue. Unlike most commercial approaches that produce tiny meat fragments later assembled with binders or scaffolds, this method creates a single coherent piece with more natural structure and texture. This is the first working model using tubes to grow muscle tissue into a thick slab, according to Mark Post, chief science officer at Mosa Meat, who created the world's first lab-grown hamburger in 2013. Significant hurdles remain before commercialization. The hollow fibers aren't edible and must be manually removed. Researchers are exploring automating this process or creating edible alternatives using cellulose.

Read more of this story at Slashdot.

msmash