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Study Links Microplastic Exposure to Alzheimer's Disease in Mice

1 month ago
Micro- and nanoplastic particles "infiltrate all systems of the body, including the brain," notes the University of Rhode Island, "where they can accumulate and trigger Alzheimer's-like conditions, according to a new study by researchers in the University of Rhode Island College of Pharmacy." ScienceDaily shares the announcement: After a previous study that showed how microplastics can infiltrate all systems of the body — including the blood-brain barrier, which protects the brain from harmful substances as small as viruses and bacteria — University of Rhode Island pharmacy assistant professor Jaime Ross expanded the study to determine the brain health impacts of the plastic toxins. Her findings indicate that the accumulation of micro- and nanoplastics in the brain can lead to cognitive decline and even Alzheimer's disease, especially in those who carry genetic risk factors. Ross' latest study, published recently in the journal Environmental Research Communications, examined mice that had been genetically modified to include the naturally occurring gene APOE4, a strong indicator of Alzheimer's risk making people 3.5 times more likely to develop the disease than those who carry the APOE3 variant of the gene that is passed from parents to offspring... Ross and her team exposed two groups of mice — one with the APOE4 variant and one with APOE3 — to micro- and nanoplastics in their drinking water over a period of three weeks. The tiny particles from polystyrene — among the most abundant plastics in the world, found in Styrofoam take-out containers, plastic cups and more — infiltrated the mice' organs, including the brain, as expected... Ross' team then ran the mice through a series of tests to examine their cognitive ability, beginning with an open-field test, in which researchers put a mouse in a chamber and allow it to explore at will for 90 minutes. Ordinarily, a mouse will hug the walls, naturally attempting to hide from potential predators. However, after microplastic exposure, the APOE4 mice — especially the male mice — tended to wander more in the middle of the chamber and spend time in open space, leaving themselves vulnerable to predators... The results are concerning enough to warrant further study into the cognitive decline caused by exposure to micro- and nanoplastics, which are among the most prominent environmental toxins to which people are routinely exposed... Ross is continuing to expand her research into the topic and encourages others to do so, in the hope of leading to better regulation of the toxins.

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EditorDavid

Is OpenAI's Video-Generating Tool 'Sora' Scraping Unauthorized YouTube Clips?

1 month ago
"OpenAI's video generation tool, Sora, can create high-definition clips of just about anything you could ask for..." reports the Washington Post. "But OpenAI has not specified which videos it grabbed to make Sora, saying only that it combined 'publicly available and licensed data'..." With ChatGPT, OpenAI helped popularize the now-standard industry practice of building more capable AI tools by scraping vast quantities of text from the web without consent. With Sora, launched in December, OpenAI staff said they built a pioneering video generator by taking a similar approach. They developed ways to feed the system more online video — in more varied formats — including vertical videos and longer, higher-resolution clips... To explore what content OpenAI may have used, The Washington Post used Sora to create hundreds of videos that show it can closely mimic movies, TV shows and other content... In dozens of tests, The Post found that Sora can create clips that closely resemble Netflix shows such as "Wednesday"; popular video games like "Minecraft"; and beloved cartoon characters, as well as the animated logos for Warner Bros., DreamWorks and other Hollywood studios, movies and TV shows. The publicly available version of Sora can generate only 20-second clips, without audio. In most cases, the look-alike scenes were made by typing basic requests like "universal studios intro." The results also showed that Sora can create AI videos with the logos or watermarks that broadcasters and tech companies use to brand their video content, including those for the National Basketball Association, Chinese-owned social app TikTok and Amazon-owned streaming platform Twitch... Sora's ability to re-create specific imagery and brands suggests a version of the originals appeared in the tool's training data, AI researchers said. "The model is mimicking the training data. There's no magic," said Joanna Materzynska, a PhD researcher at Massachusetts Institute of Technology who has studied datasets used in AI. An AI tool's ability to reproduce proprietary content doesn't necessarily indicate that the original material was copied or obtained from its creators or owners. Content of all kinds is uploaded to video and social platforms, often without the consent of the copyright holder... Materzynska co-authored a study last year that found more than 70 percent of public video datasets commonly used in AI research contained content scraped from YouTube. Netflix and Twitch said they did not have a content partnership for training OpenAI, according to the article (which adds that OpenAI "has yet to face a copyright suit over the data used for Sora.") Two key quotes from the article: "Unauthorized scraping of YouTube content continues to be a violation of our Terms of Service." — YouTube spokesperson Jack Malon "We train on publicly available data consistent with fair use and use industry-leading safeguards to avoid replicating the material they learn from." — OpenAI spokesperson Kayla Wood

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EditorDavid