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A CRISPR-based drug given to study participants by infusion is raising hopes for a much easier way to lower cholesterol, reports CNN: With a snip of a gene, doctors may one day permanently lower dangerously high cholesterol, possibly removing the need for medication, according to a new pilot study published Saturday in the New England Journal of Medicine. The study was extremely small — only 15 patients with severe disease — and was meant to test the safety of a new medication delivered by CRISPR-Cas9, a biological sort of scissor which cuts a targeted gene to modify or turn it on or off. Preliminary results, however, showed nearly a 50% reduction in low-density lipoprotein, or LDL, the "bad" cholesterol which plays a major role in heart disease — the No.1 killer of adults in the United States and worldwide. The study, which will be presented Saturday at the American Heart Association Scientific Sessions in New Orleans, also found an average 55% reduction in triglycerides, a different type of fat in the blood that is also linked to an increased risk of cardiovascular disease. "We hope this is a permanent solution, where younger people with severe disease can undergo a 'one and done' gene therapy and have reduced LDL and triglycerides for the rest of their lives," said senior study author Dr. Steven Nissen, chief academic officer of the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic in Ohio.... Today, cardiologists want people with existing heart disease or those born with a predisposition for hard-to-control cholesterol to lower their LDL well below 100, which is the average in the US, said Dr. Pradeep Natarajan, director of preventive cardiology at Massachusetts General Hospital and associate professor of medicine at Harvard Medical School in Boston... People with a nonfunctioning ANGPTL3 gene — which Natarajan says applies to about 1 in 250 people in the US — have lifelong levels of low LDL cholesterol and triglycerides without any apparent negative consequences. They also have exceedingly low or no risk for cardiovascular disease. "It's a naturally occurring mutation that's protective against cardiovascular disease," said Nissen, who holds the Lewis and Patricia Dickey Chair in Cardiovascular Medicine at Cleveland Clinic. "And now that CRISPR is here, we have the ability to change other people's genes so they too can have this protection." "Phase 2 clinical trials will begin soon, quickly followed by Phase 3 trials, which are designed to show the effect of the drug on a larger population, Nissen said." And CNN quotes Nissen as saying "We hope to do all this by the end of next year. We're moving very fast because this is a huge unmet medical need — millions of people have these disorders and many of them are not on treatment or have stopped treatment for whatever reason."

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Mason Storm created the controversial work that has left many 'disgusted.' The British artist has left the interpretation up to the viewer to determined if Trump is a sinner or a saint.

Dr Martin Whyte, who is currently employed by Northumbria Healthcare NHS Foundation Trust as a specialist trainee in paediatrics, has escaped being struck off by the General Medical Council.

EXCLUSIVE: The Hollywood star, 63, was helicoptered into Saint Hill Manor, the church's British Base in East Grinstead, Sussex, on Sunday to take part in the three day-event amid protests.

Her outlook is good: treatment for the disease, which affects 55,000 women a year in the UK, is now excellent and catching it early gives her the best possible chance of beating it fast.

A former Business Analyst reportedly filed a class action lawsuit claiming that for years, hundreds of remote employees at Bank of America first had to boot up complex computer systems before their paid work began, reports Human Resources Director magazine: Tava Martin, who worked both remotely and at the company's Jacksonville facility, says the financial institution required her and fellow hourly workers to log into multiple security systems, download spreadsheets, and connect to virtual private networks — all before the clock started ticking on their workday. The process wasn't quick. According to the filing in the United States District Court for the Western District of North Carolina, employees needed 15 to 30 minutes each morning just to get their systems running. When technical problems occurred, it took even longer... Workers turned on their computers, waited for Windows to load, grabbed their cell phones to request a security token for the company's VPN, waited for that token to arrive, logged into the network, opened required web applications with separate passwords, and downloaded the Excel files they needed for the day. Only then could they start taking calls from business customers about regulatory reporting requirements... The unpaid work didn't stop at startup. During unpaid lunch breaks, many systems would automatically disconnect or otherwise lose connection, forcing employees to repeat portions of the login process — approximately three to five minutes of uncompensated time on most days, sometimes longer when a complete reboot was required. After shifts ended, workers had to log out of all programs and shut down their computers securely, adding another two to three minutes. Thanks to Slashdot reader Joe_Dragon for sharing the article.

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Ibrahim Wanas, owner of Ritzy Barbers in Fletton, Peterborough, has detailed for the first time how his staff were threatened with a large knife just hours before the Huntingdon train attack.

Billed simply as 'An interview with HRH The Princess of Wales', with no hint of what was to come, the programme would turn out to be the most controversial broadcast by the BBC.

BBC newsreader Martine Croxall was introducing a news bulletin in June this year when she changed the autocue from 'pregnant people' to 'women' live on air.

The Associated Press reports that "For the past decade, Dr. Priscilla Chan and her husband Mark Zuckerberg have focused part of their philanthropy on a lofty goal — 'to cure, prevent or manage all disease' — if not in their lifetime, then in their children's." During that decade they also funded other initiatives (including underprivileged schools and immigration reform), according to the article. But there's a change coming: Now, the billionaire couple is shifting the bulk of their philanthropic resources to Biohub, the pair's science organization, and focusing on using artificial intelligence to accelerate scientific discovery. The idea is to develop virtual, AI-based cell models to understand how they work in the human body, study inflammation and use AI to "harness the immune system" for disease detection, prevention and treatment. "I feel like the science work that we've done, the Biohub model in particular, has been the most impactful thing that we have done. So we want to really double down on that. Biohub is going to be the main focus of our philanthropy going forward," Zuckerberg said Wednesday evening at an event at the Biohub Imaging Institute in Redwood City, California.... Chan and Zuckerberg have pledged 99% of their lifetime wealth — from shares of Meta Platforms, where Zuckerberg is CEO — toward these efforts... On Thursday, Chan and Zuckerberg also announced that Biohub has hired the team at EvolutionaryScale, an AI research lab that has created large-scale AI systems for the life sciences... Biohub's ambition for the next years and decades is to create virtual cell systems that would not have been possible without recent advances in AI. Similar to how large language models learn from vast databases of digital books, online writings and other media, its researchers and scientists are working toward building virtual systems that serve as digital representations of human physiology on all levels, such as molecular, cellular or genome. As it is open source — free and publicly available — scientists can then conduct virtual experiments on a scale not possible in physical laboratories. "We will continue the model we've pioneered of bringing together scientists and engineers in our own state-of-the-art labs to build tools that advance the field," according to Thursday's blog post. "We'll then use those tools to generate new data sets for training new biological AI models to create virtual cells and immune systems and engineer our cells to detect and treat disease.... "We have also established the first large-scale GPU cluster for biological research, as well as the largest datasets around human cell types. This collection of resources does not exist anywhere else."

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The Loose Women host, 65, lost her father Dennis in 2012 from complications from dementia, with her mother, Joan, 94, also being diagnosed with the disease.

Long-time Slashdot reader AmiMoJo shared this report from Marine Insight: The world's largest cargo sailboat, Neoliner Origin, completed its first transatlantic voyage on 30 October despite damage to one of its sails during the journey. The 136-metre-long vessel had to rely partly on its auxiliary motor and its remaining sail after the aft sail was damaged in a storm shortly after departure... Neoline, the company behind the project, said the damage reduced the vessel's ability to perform fully on wind power... The Neoliner Origin is designed to reduce greenhouse gas emissions by 80 to 90 percent compared to conventional diesel-powered cargo ships. According to the United Nations Conference on Trade and Development (UNCTAD), global shipping produces about 3 percent of worldwide greenhouse gas emissions... The ship can carry up to 5,300 tonnes of cargo, including containers, vehicles, machinery, and specialised goods. It arrived in Baltimore carrying Renault vehicles, French liqueurs, machinery, and other products. The Neoliner Origin is scheduled to make monthly voyages between Europe and North America, maintaining a commercial cruising speed of around 11 knots.

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Despite Joe, 35, correctly guessing that Alan and Cat Burns , 25, were the remaining Traitors, he failed to convince the others and found himself being banished at the last minute.

War heroes are to be evicted from their ­historic base to make way for the UK Government 's controversial plans to house asylum seekers in MoD barracks.

Dame Susan Langley DBE becomes the third female mayor, but the first to insist that this year's Lord Mayor's Show changes its name to the Lady Mayor's Show.

George Morris, from Torrance near Glasgow , began shivering and shaking as his health declined during the arduous wait to be seen by 'frazzled' doctors.

Footage released by Kyiv shows Ukraine's Special Operations Forces (SOF) wiping out an S-400 Triumph missile launcher in the occupied Crimean village of Uyutne, near Yevpatoria.

The victim, aged in her 30s, suffered a 'serious injury' in the attack that unfolded in Birmingham city centre shortly before 9pm last night.

A 21-year-old man in Turkey suffered a severe and potentially deadly disease after following a bizarre habit to try to prepare for an upcoming race, doctors warned in a medical journal.

Video producer and AI consultant Jeremy Carrasco says his research shows that disturbing clips are being served up by algorithms typically geared towards kids.