X

Aggregator

China Pushes Boundaries With Animal Testing to Win Global Biotech Race

Slashdot
1 week 3 days ago
China is accelerating its biotech ambitions by pushing the limits of animal testing and gene editing (source paywalled; alternative source) while Western countries tighten ethical restrictions. "Editing the genes of large animals such as pigs, monkeys and dogs faces scant regulation in China," reports Bloomberg. "Meanwhile, regulators in the US and Europe demand layers of ethical reviews, rendering similar research involving large animals almost impossible." From the report: Backing the work of China's scientists is not only permissiveness but state money. In 2023 alone, the Chinese government funneled an estimated $3 billion into biotech. Its sales of cell and gene therapies are projected to reach $2 billion by 2033 from $300 million last year. On the Chinese researchers' side are government-supported breeding and research centers for gene-edited animals and a public largely in approval of pushing the boundaries of animal testing. The country should become "a global scientific and technology power," Xi said, declaring biotechnology and gene editing a strategic priority. For decades, the country's pharmaceutical companies specialized in generics, reproducing drugs already pioneered elsewhere. Delving head first into gene editing research may be key to China's plan to develop innovative drugs as well as reduce its dependence on foreign pharmaceutical companies. The result is a country that now dominates headlines with stories of large, genetically modified animals being produced for science -- and the catalog is startling. Its scientists have created monkeys with schizophrenia, autism and sleep disorders. They were the first to clone primates. They've engineered dogs with metabolic and neurological diseases, and even cloned a gene-edited beagle with a blood-clotting disorder.

Read more of this story at Slashdot.

BeauHD

CodeSOD: A Basic Mistake

The Daily WTF
1 week 3 days ago

Way back in 1964, people were starting to recgonize that computers were going to have a large impact on the world. There was not, at the time, very much prepackaged software, which meant if you were going to use a computer to do work, you were likely going to have to write your own programs. The tools to do that weren't friendly to non-mathematicians.

Thus, in 1964, was BASIC created, a language derived from experiments with languages like DOPE (The Dartmouth Oversimplified Programming Experiment). The goal was to be something easy, something that anyone could use.

In 1977, the TRS-80, the Commodore PET, and the Apple II all launched, putting BASIC into the hands of end users. But it's important to note that BASIC had already been seeing wide use for a decade on "big iron" systems, or more hobbyist systems, like the Altair 8800.

Today's submitter, Coyne, was but a humble student in 1977, and despite studying at a decent university, brand spanking new computers were a bit out of reach. Coyne was working with professors to write code to support papers, and using some dialect of BASIC on some minicomputer.

One of Coyne's peers had written a pile of code, and one simple segment didn't work. As it was just a loop to print out a series of numbers, it seemed like it should work, and work quite easily. But the programmer writing it couldn't get it to work. They passed it around to other folks in the department, and those folks also couldn't get it to work. What could possibly be wrong with this code?

3010 O = 45 3020 FOR K = 1 TO O 3030 PRINT K 3040 NEXT K

Now, it's worth noting, this particular dialect of BASIC didn't support long variable names- you could use a single letter, or you could use a letter and a number, and that was it. So the short variable names are not explicitly a problem here- that's just the stone tools which were available to programmers at the time.

For days, people kept staring at this block, trying to figure out what was wrong. Finally, Coyne took a glance, and in a moment was able to spot the problem.

I've done something nasty here, because I posted the correct block first. What the programmer had actually written was this:

3010 O = 45 3020 FOR K = 1 TO 0 3030 PRINT K 3040 NEXT K

The difference is subtle, especially when you're staring at a blurry CRT late at night in the computer lab, with too little coffee and too much overhead lighting. I don't know what device they were using for display; most terminals made sure to make O look different from 0, but I couldn't be bold enough to say all of them did. And, in this era, you'd frequently review code on printed paper, so who knows how it was getting printed out?

But that, in the end, was the problem- the programmer accidentally typed a zero where they meant the letter "O". And that one typo was enough to send an entire computer science department spinning for days when no one could figure it out.

In any case, it's interesting to see how an "easy" to use language once restricted variable names to such deep inscrutability.

[Advertisement] BuildMaster allows you to create a self-service release management platform that allows different teams to manage their applications. Explore how!
Remy Porter

Westinghouse Is Claiming a Nuclear Deal Would See $80 Billion of New Reactors

Slashdot
1 week 3 days ago
An anonymous reader quotes a report from Ars Technica: On Tuesday, Westinghouse announced that it had reached an agreement with the Trump administration that would purportedly see $80 billion of new nuclear reactors built in the US. And the government indicated that it had finalized plans for a collaboration of GE Vernova and Hitachi to build additional reactors. Unfortunately, there are roughly zero details about the deal at the moment. The agreements were apparently negotiated during President Trump's trip to Japan. An announcement of those agreements indicates that "Japan and various Japanese companies" would invest "up to" $332 billion for energy infrastructure. This specifically mentioned Westinghouse, GE Vernova, and Hitachi. This promises the construction of both large AP1000 reactors and small modular nuclear reactors. The announcement then goes on to indicate that many other companies would also get a slice of that "up to $332 billion," many for basic grid infrastructure. The report notes that no reactors are currently under construction and Westinghouse's last two projects ended in bankruptcy. According to the Financial Times, the government may share in profits and ownership if the deal proceeds.

Read more of this story at Slashdot.

BeauHD